The convergence of climate impacts and security threats is having a confounding and detrimental impact on health access and outcomes, further fueling environmental, social and financial uncertainty. These crises are complex and unfolding during a time of heightened global conscience and when global and local leadership are negotiating and re-aligning a “new public health order.” Decision makers are forced to prioritize, mitigate risk and foster innovation across investments and program interventions. During this forum, we will navigate dynamic geopolitical and philanthropic forces while balancing global and local ecosystems that impact health delivery. We will also acknowledge and explore the economic ambiguity that is the direct result of the trending environmental and social unpredictability.