Multi-sector partnerships are the cornerstone to increasing access to quality healthcare and an imperative to addressing and engaging with disasters and longer-term humanitarian response. Given the increase in crises and projected trajectory, the shifting funding environment, and an unprecedented level of humanitarian need, we will focus on and explore the impact and scalability of new, equitable and flexible models of partnership. Sessions will also look at scaling the other tools in our tool box from technological innovations, to lessons learned from recent health crises, and early warning systems as well as other resources that can help us strategize for the future. The GHPF will conclude with a discussion of the challenge of keeping humanity at the center of all the global efforts to address the confluence of crises which may be the beacon necessary to embrace true transformative change.